Bad Medicine #1 (2012) introduces readers to a gripping fusion of medical mystery and supernatural horror, kicking off a bold and cerebral series from Oni Press. Written by Nunzio DeFilippis and Christina Weir, with dynamic artwork by Christopher Mitten, this debut issue establishes a unique tone—equal parts investigative thriller and eerie sci-fi tale.

The story centres on the enigmatic Dr. Randal Horne, a once-prominent physician who vanished under scandalous circumstances. Years later, he resurfaces as the only man capable of solving a baffling case involving a man whose head has mysteriously disappeared—without any sign of trauma. Recruited by the NYPD for his unorthodox approach and unmatched medical insight, Horne joins a team of specialists to uncover the truth behind what appears to be a deadly new form of pathology… one that defies all scientific logic.

DeFilippis and Weir craft a smart, fast-paced script that delves into questions of ethics, science, and belief in the face of the unexplainable. Dr. Horne is a compelling protagonist—brilliant, broken, and reluctantly drawn back into a world he tried to escape. His interactions with the investigative team—particularly with sharp-witted medical examiner Joanna Scott—set the stage for layered dynamics and emotional depth in future issues.

Christopher Mitten’s art adds gritty realism with a touch of the surreal. His expressive characters and shadowed environments pull readers into a world where the boundaries between science and the supernatural are increasingly blurred. Bill Crabtree’s colour work complements the mood perfectly, balancing clinical sterility with creeping dread.

As a first issue, Bad Medicine #1 excels at world-building without sacrificing pace. It’s an ideal entry point for readers who enjoy cerebral storytelling with horror undertones—think The X-Files meets House M.D., with a dash of Lovecraftian influence.

Available now at ComicBookXS.com, this debut issue is in excellent condition. Orders are swiftly handled and sent in solid, carefully reinforced packaging to ensure your comic arrives pristine and ready for display or collecting.

Add Bad Medicine #1 to your library today and discover a world where cutting-edge science meets the unexplainable—and where one flawed genius might be the last hope against the impossible.